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The proinflammatory phenotype is the dominant phenotype of immune cells in T2DM. In T2DM, M1 macrophages are definitely the dominant immune cells that bring about inflammation in islets.352,353,354 The expression amounts of PPARγ in macrophages from T2DM sufferers are diminished, and macrophage-precise PPARγ controls M2 macrophage activation.355,